Identifying Prodromal Parkinson's Disease: Pre-Motor Disorders in Parkinson's Disease
Identifieur interne : 001097 ( Main/Exploration ); précédent : 001096; suivant : 001098Identifying Prodromal Parkinson's Disease: Pre-Motor Disorders in Parkinson's Disease
Auteurs : Ronald B. Postuma [Canada] ; Dag Aarsland [Norvège] ; Paolo Barone [Italie] ; David J. Burn [Royaume-Uni] ; Christopher H. Hawkes [Royaume-Uni] ; Wolfgang Oertel [Allemagne] ; Tjalf Ziemssen [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Increasing recognition that Parkinson's disease (PD) may start outside of the substantia nigra has led to a rapidly expanding effort to define prodromal stages of PD, before motor signs permit classical diagnosis. Many of these efforts center around the identification of clinical non-motor symptoms and signs of disease. There is now direct evidence that olfaction, rapid eye movement (REM) sleep behavior disorder (RBD), constipation, and depression can be present in prodromal PD. In addition, there is suggestive evidence that visual changes, other autonomic symptoms, and subtle cognitive changes may also be present at prodromal stages. A critical issue in utility of these prodromal markers will be assessment of sensitivity, specificity, and positive and negative predictive values. Although these have yet to be fully defined, olfactory deficits, some visual changes, and autonomic symptoms occur in the majority of PD patients at diagnosis, suggesting good potential sensitivity. However, with the exception of RBD and perhaps some specific autonomic measures, specificity, and positive predictive value of these markers may be insufficient to be used alone as identifiers of prodromal disease. The evidence for the utility of olfaction, RBD, autonomic markers, visual changes, mood disorders, and cognitive loss as markers of prodromal PD and the potential sensitivity and specificity of these markers are summarized.
Affiliations:
- Allemagne, Canada, Italie, Norvège, Royaume-Uni
- Angleterre, District de Dresde, District de Giessen, Grand Londres, Hesse (Land), Québec, Saxe (Land)
- Dresde, Londres, Marbourg, Montréal
- Université McGill, Université technique de Dresde
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Postuma</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, McGill University, Montreal General Hospital</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Quebec</wicri:noRegion><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centre d'Études Avancées en Médecine du Sommeil, Hopital du Sacre-Coeur</s1><s2>Montreal</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Old Age Psychiatry, Psychiatric Clinic, Stavanger University Hospital</s1><s2>Stavanger</s2><s3>NOR</s3><sZ>2 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centro per le Malattie Neurodegenerative, University of Salerno</s1><s2>Salerno</s2><s3>ITA</s3><sZ>3 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Salerno</wicri:noRegion></affiliation></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute for Ageing and Health, Newcastle University</s1><s2>Newcastle upon Tyne</s2><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Hawkes, Christopher H" sort="Hawkes, Christopher H" uniqKey="Hawkes C" first="Christopher H." last="Hawkes">Christopher H. Hawkes</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Neuroscience Centre, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry</s1><s2>London</s2><s3>GBR</s3><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Oertel, Wolfgang" sort="Oertel, Wolfgang" uniqKey="Oertel W" first="Wolfgang" last="Oertel">Wolfgang Oertel</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, Philipps-Universität</s1><s2>Marburg</s2><s3>DEU</s3><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Ziemssen, Tjalf" sort="Ziemssen, Tjalf" uniqKey="Ziemssen T" first="Tjalf" last="Ziemssen">Tjalf Ziemssen</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Autonomes und neuroendokrinologisches Funktionslabor, Neurologische Klinik und Poliklinik, Universitätsklinikum Carl Gustav Carus</s1><s2>Technische Universität Dresden</s2><s3>DEU</s3><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><settlement type="city">Dresde</settlement><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region></placeName><orgName type="university">Université technique de Dresde</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Motor system disorder</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Prediction</term><term>Prodrome</term><term>Sensitivity</term><term>Specificity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Trouble moteur</term><term>Pathologie du système nerveux</term><term>Prédiction</term><term>Sensibilité</term><term>Spécificité</term><term>Prodrome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Increasing recognition that Parkinson's disease (PD) may start outside of the substantia nigra has led to a rapidly expanding effort to define prodromal stages of PD, before motor signs permit classical diagnosis. Many of these efforts center around the identification of clinical non-motor symptoms and signs of disease. There is now direct evidence that olfaction, rapid eye movement (REM) sleep behavior disorder (RBD), constipation, and depression can be present in prodromal PD. In addition, there is suggestive evidence that visual changes, other autonomic symptoms, and subtle cognitive changes may also be present at prodromal stages. A critical issue in utility of these prodromal markers will be assessment of sensitivity, specificity, and positive and negative predictive values. Although these have yet to be fully defined, olfactory deficits, some visual changes, and autonomic symptoms occur in the majority of PD patients at diagnosis, suggesting good potential sensitivity. However, with the exception of RBD and perhaps some specific autonomic measures, specificity, and positive predictive value of these markers may be insufficient to be used alone as identifiers of prodromal disease. The evidence for the utility of olfaction, RBD, autonomic markers, visual changes, mood disorders, and cognitive loss as markers of prodromal PD and the potential sensitivity and specificity of these markers are summarized.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Italie</li><li>Norvège</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>District de Dresde</li><li>District de Giessen</li><li>Grand Londres</li><li>Hesse (Land)</li><li>Québec</li><li>Saxe (Land)</li></region><settlement><li>Dresde</li><li>Londres</li><li>Marbourg</li><li>Montréal</li></settlement><orgName><li>Université McGill</li><li>Université technique de Dresde</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name></region><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name></country><country name="Norvège"><noRegion><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name></noRegion><name sortKey="Hawkes, Christopher H" sort="Hawkes, Christopher H" uniqKey="Hawkes C" first="Christopher H." last="Hawkes">Christopher H. Hawkes</name></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Oertel, Wolfgang" sort="Oertel, Wolfgang" uniqKey="Oertel W" first="Wolfgang" last="Oertel">Wolfgang Oertel</name></region><name sortKey="Ziemssen, Tjalf" sort="Ziemssen, Tjalf" uniqKey="Ziemssen T" first="Tjalf" last="Ziemssen">Tjalf Ziemssen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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